ژنتیک نوروپاتی دیابتی: بررسی نقش ژن VEGF

Authors

  • بولتون, آندره
  • توکّلی بزّاز, جواد
  • هاچینسون, یان
  • پراویکا, ورا
Abstract:

Background: Vascular factors in conjunction with metabolic issues are involved in both etiopathogenesis of diabetic neuropathy (DNU), and more remarkably in "repair" phase, when the net balance between neuroregenerative/degenerative reactions is dictated to some extent by these factors. The ischemic nature of DNU indicates the importance of re-establishment of blood vessels. VEGF, a growth factor which, in addition to its hemodynamic effects, possesses an "angiogenic" capacity has been the subject of extensive investigations in DNU, especially, interventional therapies. The impacts of racial and inherited backgrounds in the development of DNU suggest that the genetic issues partially govern the outcome of diabetic late complications, including DNU. By conducting a candidate gene case-control association study, present study explores the possibility if the inter-individual variations of VEGF gene structure by any means encode the genetic susceptibility/resistance in the course of DNU. Methods: The distribution of VEGF gene polymorphisms frequencies were analyzed at positions –7*C/T, -1001*G/C, -1154*G/A and –2578*C/A and were evaluated by ARMS-PCR in 248 type 1 diabetic subjects (81 DNU+, 167 DNU−) and 113 healthy controls, all from "British-Caucasian" origin. Results: When the frequency of the polymorphic alleles/genotypes between patients and controls, and also between two subgroups within patients' group with each other (DNU+ vs. DNU−) or with healthy controls were compared, only in one situation a significant difference was evident. The distribution of a VEGF gene polymorphism at promoter region (–7*C/T) at allelic (but not at genotypic) level was notably different between diabetics, with and without neuropathy, while the minor allele (T) conferred a protective effect (P=0.03 OR = 1.75).Conclusion: The present study may imply a prognostic value for VEGF gene polymorphism at promoter region (–7*C/T) in DNU. However, it requires further studies to appreciate better the phenotypic impact of this polymorphism in this chronic complication of diabetes. A catalog of candidate genes polymorphisms that functionally reflect a protection/predisposition to DNU can provide the genotypic profile that can be useful to reasonably predict the overall behavior of diabetic subjects to the metabolic derangements relative to development of DNU, which in turn may require adoption of relevant preventive and therapeutic measures.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

ژنتیک رتینوپاتی دیابتی: بررسی نقش ژن VEGF

Background: VEGF is newly discovered growth factor that has diverse biologic properties. The bottom-line of these activities is conduction and orchestration of a series of reactions that are taking place at microvasculature of different tissues/organs. Among the growth factors, cytokines and other mediators that reflect meaningful alteration in their local/systemic level, VEGF is the distinct p...

full text

ژنتیک نفروپاتی دیابتی: بررسی نقش ژن TGF-1

Background: Despite substantial progress in the clinical management of diabetes, diabetic nephropathy (DN) still occurs recurrently, implicating diabetes as the major underlying condition leading to the end stage renal disease. One of the main reasons is the influential role of genetic or inherited backgrounds of diabetics that are almost overlooked in daily practice. Owing to be orchestrated b...

full text

بررسی ارتباط بین پلی مورفیسم ژن vegf و رتینوپاتی دیابتی در بیماران دیابتی نوع 2

چکیده فارسی : رتینوپاتی دیابتی یکی از عوارض شایع میکروواسکولار در بیماران دیابتی است که یکی از عوامل مهم نابینایی در جهان محسوب می شود. vascular endothelial growth factorبه عنوان یک فاکتور آنژیوژنز قوی و هم چنین فاکتور نفوذپذیری عروق نقش مهمی را در ایجاد عوارض دیابت ایفا می کند. در تحقیق حاضر dna جدا شده از 200 بیمار دارای دیابت انجام شد که 101 نفر از آن ها دارای رتینوپاتی دیابتی (dr) و 99...

15 صفحه اول

بررسی ارتباط نوروپاتی دیابتی با غلظت هموگلوبین گلیکوزیله

    Background & Aim: Diabetic neuropathy occurs in approximately 50% of individuals with long-standing type I and type II DM(Diabetes Mellitus). The pathology of diabetic neuropathy involves oxidative stress, advanced glycation end products, polyol pathway flux, and protein kinase C activation.The purpose of this study was screening for diabetic neuropathy and analysing the relation between Hb...

full text

بررسی رابطه بین عوارض نوروپاتی و کیفیت زندگی بیماران دیابتی

Background: Neuropathy is one of the most common and dangerous complications of diabetes. Diabetic neuropathy account as the most common cause of mortality among patients. Many studies suggest that neuropathy have a negative effect on quality of life. Although there is limited evidences about relationship between diabetic neuropathy and quality of life in Iran, so this study was conducted to in...

full text

نوروپاتی محیطی در بیماران دیابتی و عوامل مؤثر برآن

At least 2 million people are affected by type II diabetes mellitus in Iran. Neuropathy is one of the commonest complications of diabetes affecting the quality of life of patients and can result in foot ulcer and amputation. The current study aimed to examine possible factors that could alter development of diabetic neuropathy.Methods: In this case-control study, 110 diabetic patients were sele...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 5  issue None

pages  117- 125

publication date 2005-09

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023